The laboratory of preclinical brain imaging (PBI Lab) is settled at the Department of Biomedical Engineering and Radiological Sciences (BIRS) at National Yang Ming Chiao Tung University (NYCU) in mid-2020 after Dr. Kao joined the current department. PBI Lab aims to probe the functional and metabolic changes along disease progression using the most advanced MR technique in preclinical models. PBI lab has implemented multi-model and translation MRI techniques to measure blood flow, blood volume, water diffusion, white-matter integrity, blood-brain-barrier disruption, and network changes in both rats and mice. With the close collaboration with physicians and continuous dialogue with clinical experts, PBI lab intends to study clinical-relevant issues including mild traumatic brain injury, brain tumors, ischemic or hemorrhagic stroke, ischemic hypoxia and etc. with advanced neuroimaging. Dr. Kao’s experience in cutting-edge electrophysiology and MRI techniques put her in a very unique position to bring innovations to the field of neuroscience research. Together with the clinical- relevant animal models, multi-parametric MRI, and quantitative image analysis, PBI lab is currently on the path carrying out leading research in the field of translational neuroimaging.