Laboratory of
Preclinical Brain Imaging

Our Mission

Preclinical imaging research for reverse TRANSLATIONAL RESEARCH (rTR)

Aim 1

Develop clinical-relevant neurological disease models

Aim 2

Apply advanced and translational neuroimaging technique

Aim 3

Translate our findings to improve diagnostic or prognostic assessment

Lab PI


Yu-Chieh Jill Kao, Ph.D.| Fellow HEA

About Jill Kao and PBI Lab

The laboratory of preclinical brain imaging (PBI Lab) is settled at the Department of Biomedical Engineering and Radiological Sciences (BIRS) at National Yang Ming Chiao Tung University (NYCU) in mid-2020 after Dr. Kao joined the current department. PBI Lab aims to probe the functional and metabolic changes along disease progression using the most advanced MR technique in preclinical models. PBI lab has implemented multi-model and translation MRI techniques to measure blood flow, blood volume, water diffusion, white-matter integrity, blood-brain-barrier disruption, and network changes in both rats and mice. With the close collaboration with physicians and continuous dialogue with clinical experts, PBI lab intends to study clinical-relevant issues including mild traumatic brain injury, brain tumors, ischemic or hemorrhagic stroke, ischemic hypoxia and etc. with advanced neuroimaging. Dr. Kao’s experience in cutting-edge electrophysiology and MRI techniques put her in a very unique position to bring innovations to the field of neuroscience research. Together with the clinical- relevant animal models, multi-parametric MRI, and quantitative image analysis, PBI lab is currently on the path carrying out leading research in the field of translational neuroimaging.

  • 2020-presesnt Assistant Professor, Dept. BIRS, NYCU
  • 2022-present Higher Education Acadamey Fellowship
  • 2014-2019 Assistant Research Fellow, Neuroscience Research Center, Taipei Medical University
  • 2012-2014 Postdoc Associate, University of North Carolina, Chapel Hill, NC
  • Ph.D. from Institute of Biomedical Engineering, National Taiwan University, Taiwan
  • B.S. from Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taiwan
Current projects

Research Interests



To probe the change in brain connectivity to predict behavioral and neuropathological outcomes after mTBI

Neonatal hypoxic ischemia

To  establish early neuroimage profiles using advanced MRI to correlate with the following developmental outcomes after neonatal hypoxic ischemia


To explore different neurovascular events in the hyperacute phase of stroke and to identify how various tissue type responds to reperfusion